MACrO2

What is MACrO2?

MACrO2 is a clinical research study for people with Mycobacterium avium complex (MAC) lung disease. The study is researching epetraborole, which may be able to help fight the bacteria that cause MAC lung disease.

What will happen during the study?

Study participation lasts between 6 to 18 months. If you join the study, you will be asked to do the following:

1.) Continue to take prescribed medication(s) for MAC lung disease

2.) Take 2 tablets of epetraborole (the study medication) or a placebo (contains no active ingredients) once per day

3.) Answer questionnaires in the study app

4.) Visit the study site every 1 to 3 months to have study health assessments, including urine, blood, and sputum samples

For directions on how to collect the sputum sample, watch the instructional video.

Know that you can stop participating in a clinical research study at any time, for any reason.

Who can join MACrO2?

You may be eligible to join MACrO2 if you meet the following criteria*:

• 18 years or older
• Diagnosed with MAC lung disease
• Experiencing at least 2 of the following symptoms:
• cough with sputum (wet cough)
• dry cough
• coughing up blood
• chest congestion
• shortness of breath
• fatigue
• night sweats or unusual sweating

*Other criteria apply.

Talk to your doctor or reach out to a study site near you to learn if you may be eligible.